Wegovy has become a popular weight loss medication. But it's not the only option.
Supply shortages, cost concerns, or individual health needs may lead you to consider alternatives. Understanding what's available helps you make informed decisions with your healthcare provider.
This guide explores Wegovy substitutes and what to know before choosing one.
Why People Look for Wegovy Alternatives
Several reasons prompt people to seek other options:
• Availability issues – Supply shortages can delay treatment
• Cost concerns – Wegovy may not fit every budget
• Side effects – Some people experience unwanted effects
• Administration preference – Not everyone wants weekly injections
• Insurance coverage – Your plan may cover alternatives differently
• Individual health needs – Specific conditions may make other medications more appropriate
When prescribed by a licensed medical provider, and when clinically appropriate, several alternatives may support your weight management goals.
Understanding GLP-1 Receptor Agonists
Wegovy belongs to a class of medications called GLP-1 receptor agonists. These medications work by mimicking a natural hormone in your body.
They may help by:
• Reducing appetite
• Slowing stomach emptying
• Supporting blood sugar regulation
• Potentially decreasing cravings
Several other medications work similarly. Some work on additional pathways.
Your healthcare provider can explain which mechanism might align best with your health profile.
Injectable Alternatives to Wegovy
Zepbound (Tirzepatide)
Zepbound represents one of the closest alternatives to Wegovy. It's a once-weekly injection like Wegovy, but works slightly differently.
How it differs:
• Activates two hormone pathways (GLP-1 and GIP) instead of one
• Different dosing schedule
• Approved for additional conditions like moderate-to-severe obstructive sleep apnea
When prescribed by a licensed medical provider, and when clinically appropriate, Zepbound may be suitable for individuals who meet specific eligibility criteria.
Clinical studies have shown promising results. However, individual outcomes vary based on many factors including adherence, lifestyle modifications, and overall health status.
Learn more about tirzepatide for weight management.
Saxenda (Liraglutide)
Saxenda is another GLP-1 receptor agonist option. The key difference is frequency.
Important considerations:
• Requires daily injections rather than weekly
• Different dosage progression
• Approved for adults and adolescents ages 12 and older
• Shorter duration of action in the body
The daily injection schedule may not suit everyone's lifestyle. Some people prefer it for the flexibility to adjust quickly if needed.
Oral Medication Options
Oral Semaglutide
Oral semaglutide contains the same active ingredient as Wegovy. The difference is how you take it.
Key features:
• Once-daily tablet instead of weekly injection
• Must be taken on an empty stomach with specific instructions
• Different absorption process than injections
• May appeal to those who prefer oral medications
When prescribed by a licensed medical provider, and when clinically appropriate, oral semaglutide may offer comparable support to injectable forms.
Administration requires careful timing. You must take it first thing in the morning with plain water, then wait at least 30 minutes before eating or drinking anything else.
Non-GLP-1 Oral Options
Not all weight loss medications work on GLP-1 pathways. Other mechanisms exist.
Contrave (Naltrexone/Bupropion):
• Combination of two medications
• Works on brain pathways related to cravings and appetite
• Taken twice daily
• May be particularly relevant for emotional eating patterns
Qsymia (Phentermine/Topiramate ER):
• Combines a stimulant with a medication originally developed for seizures
• Works to suppress appetite through different mechanisms
• Once-daily dosing
• Has specific prescribing requirements
These medications have different side effect profiles and contraindications compared to GLP-1 medications. Eligibility varies based on your complete health history.
Compounded Medication Considerations
Some providers offer compounded versions of semaglutide or tirzepatide. These are medications prepared by specialty pharmacies.
Important facts about compounded medications:
• They are not FDA-approved
• Preparation methods vary between pharmacies
• May be available at different price points
• Quality standards differ from FDA-approved medications
When prescribed by a licensed medical provider, and when clinically appropriate, compounded medications may be considered. However, they come with additional considerations.
The FDA does not verify the safety, effectiveness, or quality of compounded drugs. Discuss these factors thoroughly with your healthcare provider.
Explore more about compounded GLP-1 options.
Key Factors to Consider Before Choosing
Your Health Profile
Different medications have different approval criteria. Your complete medical history matters.
Consider:
• Existing health conditions (heart disease, diabetes, sleep apnea, MASH)
• Current medications and potential interactions
• History with similar medications
• Personal or family medical history
Administration Preference
How you take medication affects adherence. Be honest about your preferences.
Weekly injections:
• Wegovy, Zepbound
• Convenient schedule
• Less frequent dosing
Daily injections:
• Saxenda
• More frequent but shorter commitment
Oral tablets:
• Oral semaglutide, Contrave, Qsymia
• No needles
• Specific timing requirements
Cost and Insurance Coverage
Pricing varies significantly between options. Insurance coverage differs too.
Factors affecting cost:
• Brand vs. compounded versions
• Insurance formulary placement
• Available manufacturer programs
• Pharmacy choice
DrMed Health offers transparent pricing for eligible patients. View our pricing options to understand potential costs.
Expected Outcomes and Timeline
All weight loss medications work differently for different people. No medication guarantees specific results.
Realistic expectations include:
• Gradual weight changes over months
• Individual variation in response
• Need for lifestyle modifications alongside medication
• Potential plateau periods
When prescribed by a licensed medical provider, and when clinically appropriate, these medications serve as tools to support: not replace: healthy eating and physical activity.
Working with Your Healthcare Provider
Choosing a weight loss medication requires medical supervision. Your provider considers factors you might not know about.
Your provider will evaluate:
• Complete medical history and current health status
• BMI and weight-related health conditions
• Previous weight loss attempts
• Contraindications for specific medications
• Realistic treatment goals
Online platforms like DrMed Health connect you with licensed medical providers who can assess your eligibility. Take our weight loss assessment to begin the evaluation process.
Eligibility varies based on individual health factors. Not everyone qualifies for every medication.
The Role of Lifestyle Modifications
No medication works alone. All weight loss medications work best alongside lifestyle changes.
Essential components include:
• Balanced nutrition approach
• Regular physical activity appropriate for your fitness level
• Adequate sleep and stress management
• Ongoing medical monitoring
Your healthcare provider should discuss these elements as part of your treatment plan.
Making Your Decision
Choosing a Wegovy alternative involves multiple considerations. There's no single "best" option for everyone.
Steps to take:
- Research available options (you're doing this now)
- Consider your personal preferences and health needs
- Discuss options with a qualified healthcare provider
- Understand the costs and coverage for your situation
- Commit to the complete treatment approach, not just medication
When prescribed by a licensed medical provider, and when clinically appropriate, several effective alternatives to Wegovy exist. The right choice depends on your unique circumstances.
DrMed Health specializes in medical weight loss through telehealth. Our licensed providers can help determine which options align with your health profile and goals. Learn how it works.
For those seeking alternatives to other medications, we also provide information on Ozempic alternatives and Wegovy alternatives.
Ready to explore your options? Start your assessment to see if you qualify for medical weight loss treatment.
Medically Reviewed: This article is for educational purposes only and does not constitute medical advice. Information presented here is based on currently available research and clinical guidelines. All weight loss medications require prescription and medical supervision.
Important Disclaimers:
• Individual results vary and are not guaranteed
• Eligibility varies based on complete health assessment
• Compounded medications are not FDA-approved
• All content is HIPAA-compliant and does not reference specific patient cases
• Consult with a licensed healthcare provider before starting any weight loss medication
About DrMed Health: We connect patients with licensed medical providers specializing in medical weight loss through secure telehealth platforms. Our providers are board-certified and licensed in their respective states. Learn more about our credentials.
Services may be available in select states including Alabama, Alaska, Arizona, Arkansas, California, Colorado, and Connecticut. Check availability in your location.